| Physiologic models can be derived from 3-dimensional
volumetric imagery (discrete digital CT scans and MRI scans) to
generate mathematical models of biological systems in a static pose.
Active biological entities do not remain in static poses. They are
restricted to certain states while being scanned, which restricts
the generated static physiological models' validity to those
specific poses. Dynamic models which impose motion can be derived
from these static models using continuous transformations. I will
discuss and review mathematical and neurosurgical issues involved in
generating, calibrating, and validating these physiologic models,
with examples in Central Nervous System (CNS) vascular physiology
and Traumatic Brain Injury (TBI). |