Mathematical Biology Seminar Abstract
Apr 21, 2016
Libin Rong
Oakland University, Department of Mathematics and Statistics
11:00 am in MSB 318 (Math Colloquium)

Hepatitis C virus dynamics: models, analysis and implications

Chronic hepatitis C virus (HCV) infection remains a public health problem worldwide. Traditional interferon-based therapy leads to viral eradication in less than 50% of treated patients. New treatment using direct-acting antiviral drugs has significantly increased the cure rate. These new drugs directly interfere with different steps of the HCV replication cycle. Thus, existing models that do not consider within-cell processes may not be optimal in analyzing data from patients treated with new drugs. In this talk, I will review mathematical models used to study HCV dynamics under traditional therapy and discuss recent advances in the development of multi-scale models for new drugs. I will address model analysis, approximation, comparison with patient data, and the implications for developing new treatment strategies for hepatitis C.